LÍNEAS DE INVESTIGACIÓN:

• SISTEMAS METABÓLICOS
• ANGIOGÉNESIS
• TRANSDUCCIÓN DE
  SEÑALES Y CÁNCER
• ProFunc: FUNCIÓN Y
  REDES DE PROTEÍNAS

DOCENCIA

OFERTAS DE TRABAJO

FOTOS

PUBLICACIONES EN REVISTAS CIENTÍFICAS:

Ranea JA, Morilla I, Lees JG, Reid A, Corin Y, Clegg A, Sanchez-Jimenez F and Orengo C.
Finding the “Dark Matter” in Human and Yeast Protein Network Prediction and Modelling.
Plos Comp. Biol. 6(9): e1000945. doi:10.1371/journal.pcbi.1000945; 2010.

Morilla I, Lees JG, Reid AJ, Orengo C, Ranea JA.
Assessment of Protein Domain Fusions in Human Protein Interaction Networks Prediction: application to the human kinetochore model.
N Biotechnol. 2010. DOI: 10.1016/j.nbt.2010.09.005. In press

Reid AJ, Ranea JA, Clegg AB, Orengo CA.
CODA: accurate detection of functional associations between proteins in eukaryotic genomes using domain fusion.
PLoS One. 5(6):e10908; 2010

Reid AJ, Ranea JA, Orengo CA.
Comparative evolutionary analysis of protein complexes in E. coli and yeast.
BMC Genomics. 11: 79; 2010.

Jagemann LR, Pérez-Rivas LG, Ruiz EJ, Ranea JA, Sánchez-Jiménez F, Nebreda AR, Alba E, Lozano J.
The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner.
J Biol Chem. 2008 Jun 20;283(25):17450-62. Epub 2008 Apr 21.

Ranea JA, Yeats C, Grant A, Orengo CA.
Predicting protein function with hierarchical phylogenetic profiles: the Gene3D Phylo-Tuner method applied to eukaryotic genomes.
PLoS Comput Biol. 2007 Nov;3(11):e237. Epub 2007 Oct 18.

Ranea JA, Sillero A, Thornton JM, Orengo CA.
Protein superfamily evolution and the last universal common ancestor (LUCA).
J Mol Evol. 2006 Oct;63(4):513-25. Epub 2006 Oct 4.

Izarzugaza JM, Juan D, Pons C, Ranea JA, Valencia A, Pazos F.
TSEMA: interactive prediction of protein pairings between interacting families.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W315-9.

Marsden RL, Ranea JA, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ, Orengo CA.
Exploiting protein structure data to explore the evolution of protein function and biological complexity.
Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):425-40. Review.

Ranea JA.
Genome evolution: micro(be)-economics.
Heredity. 2006 May;96(5):337-8.

Pazos F, Ranea JA, Juan D, Sternberg MJ.
Assessing protein co-evolution in the context of the tree of life assists in the prediction of the interactome.
J Mol Biol. 2005 Sep 30;352(4):1002-15.

Ranea JA, Grant A, Thornton JM, Orengo CA.
Microeconomic principles explain an optimal genome size in bacteria.
Trends Genet. 2005 Jan;21(1):21-5.

Ranea JA, Buchan DW, Thornton JM, Orengo CA.
Evolution of protein superfamilies and bacterial genome size.
J Mol Biol. 2004 Feb 27;336(4):871-87.

Escribano-Romero E, Jiménez-Clavero MA, Gomes P, García-Ranea JA, Ley V.
Heparansulphate mediates swine vesicular disease virus attachment to the host cell.
J Gen Virol. 2004 Mar;85(Pt 3):653-63.

Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J.
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.
Oncogene.2004 Jan 15;23(2):559-68.

Garcia-Ranea JA, Mirey G, Camonis J, Valencia A.
p23 and HSP20/alpha-crystallin proteins define a conserved sequencedomain present in other eukaryotic protein families.
FEBS Lett. 2002 Oct 9;529(2-3):162-7.

Borrego B, García-Ranea JA, Douglas A, Brocchi E.
Mapping of linear epitopes on the capsid proteins of swine vesicular disease virus using monoclonal antibodies.
J Gen Virol. 2002 Jun;83(Pt 6):1387-95.

Borrego B, Carra E, García-Ranea JA, Brocchi E.
Characterization of neutralization sites on the circulating variant of swine vesicular disease virus (SVDV): a new site is shared by SVDV and the related coxsackie B5 virus.
J Gen Virol. 2002 Jan;83(Pt 1):35-44.

iménez-Clavero MA, Douglas A, Lavery T, Garcia-Ranea JA, Ley V.
Immune recognition of swine vesicular disease virus structural proteins: novel antigenic regions that are not exposed in the capsid.
Virology.2000 Apr 25;270(1):76-83.

Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A.
Model of the ran-RCC1 interaction using biochemical and docking experiments.
J Mol Biol. 1999 Jun 18;289(4):1119-30.

Bauer B, Mirey G, Vetter IR, García-Ranea JA, Valencia A, Wittinghofer A, Camonis JH, Cool RH.
Effector recognition by the small GTP-binding proteins Ras and Ral.
J Biol Chem. 1999 Jun 18;274(25):17763-70.

Zalcman G, Dorseuil O, Garcia-Ranea JA, Gacon G, Camonis J.
RhoGAPs and RhoGDIs, (His)stories of two families.
Prog Mol Subcell Biol. 1999;22:85-113. Review. No abstract available.

García-Ranea JA, Valencia A.
Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae.
FEBS Lett. 1998 Sep 4;434(3):219-25.

Thode G, García-Ranea JA, Jiménez J.
Search for ancient patterns in protein sequences.
J Mol Evol. 1996 Feb;42(2):224-33.