ProCel - Bases Moleculares de la Proliferación Celular - Dept. Biología Molecular y Bioquímica
Universidad de Málaga
Transducción de señales y cáncer
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Publications - Relevant publications

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Fernández IF, Blanco S, Lozano J, Lazo PA.
VRK2 inhibits MAPK signaling and inversely correlates with ErbB2 in human breast cancer.
Mol Cell Biol. 30(19): 4687-97; 2010

Sánchez-Muñoz A, Gallego E, de Luque V, Pérez-Rivas LG, Vicioso L, Ribelles N, Lozano J, Alba E.
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer.
BMC Cancer. 2010 Apr 13;10(1):136.

Jagemann LR, Pérez-Rivas LG, Ruiz EJ, Ranea JA, Sánchez-Jiménez F, Nebreda AR, Alba E, Lozano J.
The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner.
J Biol Chem. 283(25): 17450-17462; 2008

Lozano J, Xing R, Cai Z, Jensen HL, Trempus C, Mark W, Cannon R, Kolesnick R.
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.
Cancer Res 63(14): 4232-4238; 2003

Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner MO, Kolesnick RN.
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans.
EMBO J. 20(18): 5114-5128; 2001

Lozano J, Morales A, Cremesti A, Fuks Z, Tilly JL, Schuchman E, Gulbins E, Kolesnick R.
Niemann-Pick Disease versus acid sphingomyelinase deficiency.
Cell Death Differ. 8(1): 100-103; 2001

Lozano J, Menendez S, Morales A, Ehleiter D, Liao WC, Wagman R, Haimovitz-Friedman A, Fuks Z, Kolesnick R.
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.
J Biol Chem. 276(1): 442-448; 2001

Xing, H.R., J. Lozano, & R. Kolesnick.
Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras.
J Biol Chem. 275(23): 17276-17280; 2000

van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Cáceres JF.
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.
J Cell Biol. 149(2): 307-316; 2000

Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R.
BAD enables ceramide to signal apoptosis via Ras and Raf-1.
J Biol Chem. 273(46): 30419-30426; 1998

García-Rocha M, Avila J, Lozano J.
The zeta isozyme of protein kinase C binds to tubulin through the pseudosubstrate domain.
Exp Cell Res. 230(1): 1-8; 1997

Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J.
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.
Mol Cell Biol. 16(1): 105-114; 1996

Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J.
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
Cell 86(5): 777-786; 1996

Municio MM, Lozano J, Sánchez P, Moscat J, Diaz-Meco MT.
Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta.
J Biol Chem. 270(26): 15884-15891; 1995

Medina MA, García de Veas R, Morata P, Lozano J, Sánchez-Jiménez F.
Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines.
Breast Cancer Res Treat. 35(2): 187-194; 1995

Berra E, Díaz-Meco MT, Lozano J, Frutos S, Municio MM, Sánchez P, Sanz L, Moscat J.
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
EMBO J. 14(24): 6157-6163; 1995

Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT.
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element.
J Biol Chem. 269(13): 10044-1049; 1994

Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J.
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.
J Biol Chem. 269(30): 19200-19202; 1994

Gil-Torregrosa B, Urdiales JL, Lozano J, Mates JM, Sanchez-Jimenez F.
Expression of different mitogen-regulated protein/proliferin mRNAs in Ehrlich carcinoma cells.
FEBS Lett. 349(3): 343-348; 1994

Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J.
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.
EMBO J. 13(12): 2842-8; 1994

Diaz-Meco MT, Lozano J, Municio MM, Berra E, Frutos S, Sanz L, Moscat J.
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
J Biol Chem. 269(50): 31706-31710; 1994

Diaz-Meco MT, Berra E, Municio MM, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera MT, Alcamí J, Payá CV
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.
Mol Cell Biol. 13(8): 4770-4775; 1993

Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J.
Protein kinase C zeta isoform is critical for mitogenic signal transduction.
Cell 74(3): 555-563; 1993




BOOKS AND BOOK CHAPTERS:

Luís G. Pérez-Rivas, Stephanie Prieto and José Lozano
Modulation of Ras signaling by the KSR family of molecular scaffolds
Emerging Signaling Pathways in Tumor Biology (Ed. P.A. Lazo)
Transworld Research Network. Kerala, India (2010)
ISBN: 978-81-7895-477-6

José Lozano y Emilio Alba
Mecanismos de invasión, metástasis y angiogénesis
(Capítulo 5, pp 85-103)
Tratado de Oncología (Tomo I)
Editores: Hernán Cortés-Funés & Ramón Colomer
Publicaciones Permanyer. Barcelona, España (2009)
ISBN: 978-84-92620-17-3

José Lozano
¿Cómo se desarrolla un cáncer?: la célula fuera de control
Encuentros con la ciencia. del macrocosmos al microcosmos
E. Gutiérrez Marí Ed. Granada, España (2007)
ISBN: 13: 978-84-612-0114-3

Brent. D. Polk, José Lozano and Richard Kolesnick
Kinase Suppressor of Ras as a Ceramide-activated Protein Kinase (Chapter 7, pp.63-73)
Ceramide Signaling (Editor, A.H. Futerman)
Landes Biosciences Publisher. Texas, USA (2002)
ISBN: 0-306-47442-5

José Lozano and Richard Kolesnick
CAP (ceramide-activated protein) kinase (pp 727-729)
Wiley Encyclopedia of Molecular Medicine
John Wiley & Sons, Inc. New York, USA (2001)
ISBN: 978-0-471-37494-7

Molecular Basis of Cell proliferation. Departament of Melecular Biology and Biochemistry. University of Malaga Campus de Teatinos s/n 29071 MÁLAGA. Teléfono: (+34) 952 13 71 35. Fax: (+34) 952 13 16 74 - 20 00.
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