ProCel - Bases Moleculares de la Proliferación Celular - Dept. Biología Molecular y Bioquímica
Universidad de Málaga
Amine system project
Versión española version española


Publications - Relevant publications


Castro-Oropeza R, Pino-Ángeles A, Khomutov MA, Urdiales JL, Moya-García AA, Vepsäläinen J, Persson L, Sarabia F, Khomutov A, Sánchez-Jiménez F.
Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence.
Amino Acids. 2014. 46(3):621-31. doi: 10.1007/s00726-013-1589-7.

Sánchez-Jiménez F, Reyes-Palomares A, Moya-García AA, Ranea JA, Medina MÁ.
Biocomputational resources useful for drug discovery against compartmentalized targets.
Curr Pharm Des. 2014;20(2):293-300.

Sánchez-Jiménez F, Ruiz-Pérez MV, Urdiales JL, Medina MA.
Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission.
Br J Pharmacol. 2013 Sep;170(1):4-16. doi: 10.1111/bph.12109.

Stegaev V, Nies AT, Porola P, Mieliauskaite D, Sánchez-Jiménez F, Urdiales JL, Sillat T, Schwelberger HG, Chazot PL, Katebe M, Mackiewicz Z, Konttinen YT, Nordström DC.
Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.
Rheumatology (Oxford). 2013 Sep;52(9):1599-608. doi: 10.1093/rheumatology/ket188.

Ruiz-Pérez MV, Sánchez-Jiménez F, Alonso FJ, Segura JA, Márquez J.
Glutamine, Glucose and other Fuels for Cancer.
Curr Pharm Des. 2013 Jun 25.

Reyes-Palomares A, Rodríguez-López R, Ranea JA, Sánchez-Jiménez F, Medina MA.
Correction: Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components.
PLoS One. 2013 Jun 18;8(6). doi: 10.1371/annotation/03fb5f25-21c7-4dfb-9d74-00a22f160bd6.

Alfonso P, Andreu V, Pino-Angeles A, Moya-García AA, García-Moreno MI, Rodríguez-Rey JC, Sánchez-Jiménez F, Pocoví M, Ortiz Mellet C, García Fernández JM, Giraldo P.
Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.
Chembiochem. 2013 May 27;14(8):943-9. doi: 10.1002/cbic.201200708.

López-Gómez C, Pino-Ángeles A, Órpez-Zafra T, Pinto-Medel MJ, Oliver-Martos B, Ortega-Pinazo J, Arnáiz C, Guijarro-Castro C, Varadé J, Álvarez-Lafuente R, Urcelay E, Sánchez-Jiménez F, Fernández Ó, Leyva L.
Candidate gene study of TRAIL and TRAIL receptors: association with response to interferon beta therapy in multiple sclerosis patients.
PLoS One. 2013 Apr 29;8(4):e62540. doi: 10.1371/journal.pone.0062540.

Reyes-Palomares A, Rodríguez-López R, Ranea JA, Sánchez Jiménez F, Medina MA.
Global analysis of the human pathophenotypic similarity gene network merges disease module components.
PLoS One. 2013;8(2):e56653. doi: 10.1371/journal.pone.0056653.

Rodríguez-Caso L, Reyes-Palomares A, Sánchez-Jiménez F, Quesada AR, Medina MÁ.
What is known on angiogenesis-related rare diseases? A systematic review of literature.
J Cell Mol Med. 2012 Dec;16(12):2872-93. doi: 10.1111/j.1582-4934.2012.01616.x.

Pino-Ángeles A, Reyes-Palomares A, Melgarejo E, Sánchez-Jiménez F.
Histamine: an undercover agent in multiple rare diseases?
J Cell Mol Med. 2012 Sep;16(9):1947-60. doi: 10.1111/j.1582-4934.2012.01566.x.

Correa-Fiz F, Reyes-Palomares A, Fajardo I, Melgarejo E, Gutiérrez A, García-Ranea JA, Medina MA, Sánchez-Jiménez F.
Regulatory cross-talk of mouse liver polyamine and methionine metabolic pathways: a systemic approach to its physiopathological consequences.
Amino Acids. 2012 Feb;42(2-3):577-95. doi: 10.1007/s00726-011-1044-6.

Reyes-Palomares A, Montañez R, Sánchez-Jiménez F, Medina MA.
A combined model of hepatic polyamine and sulfur amino acid metabolism to analyze S-adenosyl methionine availability.
Amino Acids. 2012 Feb;42(2-3):597-610. doi: 10.1007/s00726-011-1035-7.

Ruiz-Pérez MV, Pino-Ángeles A, Medina MA, Sánchez-Jiménez F, Moya-García AA.
Structural perspective on the direct inhibition mechanism of EGCG on mammalian histidine decarboxylase and DOPA decarboxylase.
J Chem Inf Model. 2012 Jan 23;52(1):113-9. doi: 10.1021/ci200221z.

Moya-Garcia AA, Rodriguez CE, Morilla I, Sanchez-Jimenez F, Ranea JA.
The function of histamine receptor H4R in the brain revealed by interaction partners.
Front Biosci (Schol Ed). 2011 Jun 1;3:1058-66.

Montañez R, Sánchez-Jiménez F, Quesada AR, Medina MÁ.
Exploring and challenging the network of angiogenesis.
Sci Rep. 2011;1:61. doi: 10.1038/srep00061.

Díez D, Sánchez-Jiménez F, Ranea JAG.
Evolutionary expansion of the Ras switch regulatory module in eukaryotes.
Nucleic Acid Res. 2011. 39(13):5526-37. doi: 10.1093/nar/gkr154

Navas-Delgado I, Real-Chicharro A, Medina MA, Sánchez-Jiménez F, Aldana-Montes JF.
Social pathway annotation: extensions of the systems biology metabolic modelling assistant.
Brief Bioinform. 2010 Oct 21. PMID: 20965999

Ruíz-Pérez MV, Sánchez-Jiménez F, Quesada AR, Medina MA
A re-evaluation of the mitogenic effect of serotonin on vascular endothelial cells.
J Biol Reg Homeos Ag. 2011 J BIOL REG HOMEOS AG. 25(1):13-20; 2011.

García-Faroldi G, Rodríguez-González C, Urdiales JL, Pérez-Pomares JM, Dávila-Cansino JC, Pejler G, Sánchez-Jiménez F, Fajardo I.
Polyamines are present in mast cell secretory granules and are important for granule homeostasis.
PLOS One. Nov 30;5(11):e15071; 2010.

Ranea JA, Morilla I, Lees JG, Reid A, Corin Y, Clegg A, Sanchez-Jimenez F and Orengo C.
Finding the “Dark Matter” in Human and Yeast Protein Network Prediction and Modelling.
Plos Comp. Biol. 6(9): e1000945. doi:10.1371/journal.pcbi.1000945; 2010.

Morilla I, Lees JG, Reid AJ, Orengo C, Ranea JA.
Assessment of Protein Domain Fusions in Human Protein Interaction Networks Prediction: application to the human kinetochore model.
N Biotechnol. 2010. DOI: 10.1016/j.nbt.2010.09.005. In press

Reid AJ, Ranea JA, Clegg AB, Orengo CA.
CODA: accurate detection of functional associations between proteins in eukaryotic genomes using domain fusion.
PLoS One. 5(6):e10908; 2010

Reid AJ, Ranea JA, Orengo CA.
Comparative evolutionary analysis of protein complexes in E. coli and yeast.
BMC Genomics. 11: 79; 2010.

Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL.
Targeting of histamine producing cells by EGCG: a green dart against inflammation?
J Physiol Biochem. 66(3): 265-70; 2010

Urreizti R, Moya-García AA, Pino-Ángeles A, Cozar M, Langkilde A, Fanhoe U, Esteves C, Arribas J, Vilaseca MA, Pérez-Dueñas B, Pineda M, González V, Artuch R, Baldellou A, Vilarinho L, Fowler B, Ribes A, Sánchez-Jiménez F, Grinberg D, Balcells S.
Molecular characterization of five patients with homocystinuria due to severe methylenetetrahydrofolate reductase deficiency.
Clin Genet. 2010 Mar 1. [Epub ahead of print]

Abrighach H, Fajardo I, Sánchez-Jiménez F, Urdiales JL.
Exploring polyamine regulation by nascent histamine in a human-transfected cell model.
Amino Acids. 38(2): 561-73; 2010

Melgarejo E, Urdiales JL, Sánchez-Jiménez F, Medina MA.
Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate.
Amino Acids. 38(2): 519-23; 2010

Schlüter A, Real-Chicharro A, Gabaldón T, Sánchez-Jiménez F, Pujol A.
PeroxisomeDB 2.0: an integrative view of the global peroxisomal metabolome.
Nucleic Acids Res. 38(Database issue): D800-5; 2010

Pino-Angeles A, Morreale A, Negri A, Sánchez-Jiménez F, Moya-García AA.
Substrate uptake and protein stability relationship in mammalian histidine decarboxylase.
Proteins. 78(1): 154-61; 2010

Melgarejo E, Urdiales JL, Sánchez-Jiménez F, Medina MA.
Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro.
Br J Pharmacol. 158(7): 1705-12; 2009

Real-Chicharro A, Ruiz-Mostazo I, Navas-Delgado I, Kerzazi A, Chniber O, Sánchez-Jiménez F, Medina MA, Aldana-Montes JF.
Protopia: a protein-protein interaction tool.
BMC Bioinformatics. 10 Suppl 12: S17; 2009

García-Faroldi G, Correa-Fiz F, Abrighach H, Berdasco M, Fraga MF, Esteller M, Urdiales JL, Sánchez-Jiménez F, Fajardo I.
Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation.
J Cell Biochem. 108(1) :261-271; 2009

Moya-García AA, Pino-Angeles A, Gil-Redondo R, Morreale A, Sánchez-Jiménez F.
Structural features of mammalian histidine decarboxylase reveal the basis for specific inhibition.
Br J Pharmacol. 157(1): 4-13; 2009

Reyes-Palomares A, Montañez R, Real-Chicharro A, Chniber O, Kerzazi A, Navas-Delgado I, Medina MA, Aldana-Montes JF, Sánchez-Jiménez F.
Systems biology metabolic modeling assistant: an ontology-based tool for the integration of metabolic data in kinetic modeling.
Bioinformatics 25(6): 834-835; 2009

de la Torre F, Moya-García AA, Suárez MF, Rodríguez-Caso C, Cañas RA, Sánchez-Jiménez F, Cánovas FM.Molecular modeling and site-directed mutagenesis reveal essential residues for catalysis in a prokaryote-type aspartate aminotransferase.
Plant Physiol. 149(4):1648-1660; 2009

García-Faroldi G, Sánchez-Jiménez F, Fajardo I.
The polyamine and histamine metabolic interplay in cancer and chronic inflammation.
Curr Opin Clin Nutr Metab Care 12(1): 59-65; 2009

Real-Chicharro A, Ruiz-Mostazo I, Navas-Delgado I, Kerzazi A, Chniber O, Sánchez-Jiménez FF, Medina MA, Aldana-Montes JF.
Protopia: a protein-protein interaction Tool.
BMC Bioinformatics 10(12):S17; 2009

Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL.
Monocyte chemoattractant protein-1: A key mediator in inflammatory processes.
Int J Biochem Cell Biol 41(5): 998-1001; 2009


Ennis M, Ciz M, Dib K, Friedman S, Gangwar RS, Gibbs BF, Levi-Schaffer F, Lojek A, Migalovich-Sheikhet H, O'Mahony L, Perecko T, Sánchez-Jiménez F, Urdiales JL, and Vasicek O. (2013). Histamine Receptors and Inflammatory Cells. In: Stark H (Ed.), HISTAMINE H4 RECEPTOR. a Novel Drug Target For Immunoregulation and Inflammation (pp. 103-144). Berlin: Versita. DOI (Chapter): 10.2478/9788376560564.c4ISBN: 9788376560564

Schwelberger HG, Ahrens F, Fogel WA, & Sánchez-Jim&eactue;nez F. (2013). Histamine Metabolism. In: Stark H (Ed.), HISTAMINE H4 RECEPTOR a Novel Drug Target For Immunoregulation and Inflammation (pp. 63-102). Berlin: Versita. DOI (Chapter): 10.2478/9788376560564.c3ISBN: 9788376560564

Melgarejo E, Medina MÁ, Sánchez-Jiménez F, Urdiales JL (2012). Potential Health Benefits of Green Tea: Role of Epigallocatechin-3-Gallate in Prevention of Inflammatory Pathologies. In: Banerjee G (Ed.), Tea Consumption and Health (pp. 39-85). Nova Publishers. ISBN: 978-1-61942-702-0

Quesada AR, Medina MÁ. (2010). Angiogenesis in Cancer: Therapeutic Targets and Angiogenesis Inhibitors In: Chatterjee M (Ed.), Angiogenesis & Therapeutic Targets in Cancer (pp. 45-67). Bentham. ISBN: 978-1-60805-007-9

Correa-Fiz F, Reyes-Palomares A, Ruiz-Pérez MV, Medina MA, Sánchez-Jiménez F.
Roles of biogenic amines in emergent and rare diseases.
Biological aspects of biogenic amines and polyamine conjugates. 339-419.
Guy Dandrifosse (Ed.). 2009
ISBN: 978-81-7895-249-9


Inventores: Sánchez-Jiménez F, Medina MA, Torés JA, Gónzalez D.
Título: Aplicación de la clorofeniramina y el histidinol en la regulación del crecimiento fúngico.
Referencia: P9601109
Fecha: 16 de marzo 1999. Entidad titular: UNIVERSIDAD DE MALAGA.

Inventores: Urdiales JL, Viguera E, Esteban A, Sánchez-Jiménez F.
Título: Aplicaciones Bioquímicas e inmunológicas de una proteína de fusión glutatión transferasa - histidina descarboxilasa de rata.
Referencia: P9800019
Fecha: 8 de enero 1998. Entidad titular: UNIVERSIDAD DE MALAGA.

Inventores: Domínguez M, Toraño A, Moreno I, Díez-Lorenzo M, Sánchez-Jiménez F, Urdiales JL.
Título: Método de obtención de anticuerpos anti-hHDC y aplicación de los mismos.
Referencia: P200600378
Referencia: WO2007093663.
Fecha: 23 de agosto 2007. Entidad titular: UNIVERSIDAD DE MALAGA.

Molecular Basis of Cell proliferation. Departament of Melecular Biology and Biochemistry. University of Malaga Campus de Teatinos s/n 29071 MÁLAGA. Teléfono: (+34) 952 13 71 35. Fax: (+34) 952 13 16 74 - 20 00.
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