Universidad de Málaga

GRUPO DE INVESTIGACIÓN: CANCERÓMICA

Genómica y proteómica del cáncer, nuevas estrategias y dianas antitumorales. Neuroquímica

Miembros
Líneas de Investigación
Publicaciones
Proyectos

PUBLICACIONES

Banerjee, M., Huang, C., Marquez, J., Mohanty, S. Probing the Structure and Function of Human Glutaminase-Interacting Protein: A Possible Target for Drug Design. Biochemistry 47, 9208-9219 (2008)

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis and carcinogenesis. Arch. Toxicol. 82, 273-299 (2008)

Olalla, L., Gutiérrez, A., Jiménez, A.J., López-Téllez, J.F., Khan, Z.U., Pérez, J., Alonso, F.J., de la Rosa, V., Campos-Sandoval, J.A., Segura, J.A., Aledo, J.C., Márquez, J. Expression of the scaffolding PDZ protein glutaminase-interacting protein in mammalian brain. J. Neurosci. Res. 86, 281-292 (2008)

Donadio, A.C., Lobo, C., Tosina, M., de la Rosa, V., Martín-Rufián, M., Campos-Sandoval, J.A., Matés, J.M., Márquez, J., Alonso, F.J., Segura, J.A. Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells. J. Cell. Biochem. 103, 800-811 (2008)

Campos-Sandoval, J.A., López de la Oliva, A.R., Lobo, C., Segura, J.A., Matés, J.M., Alonso, F.J., Márquez, J. Expression of functional human glutaminase in baculovirus system: Affinity purification, kinetic and molecular characterization. Int. J. Biochem. Cell Biol. 39, 765-773 (2007)

Márquez, J., López de la Oliva, A.R., Matés, J.M., Segura, J.A., Alonso, F.J. Glutaminase: A multifaceted protein not only involved in generating glutamate. Neurochem. Int. 48, 465-471 (2006)

Martín-Rufián, M., Segura, Lobo, C., Matés, J.M., Márquez, J., Alonso, F.J. Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by Differential Display. Cancer Biol. Ther. 5, e1-e5 (2006)

Alonso, F.J., Segura, J.A., Lora, J., Lobo, C., Fernández-Molina, B., Márquez, J., Matés, J.M. Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase. Anticancer Res. 25, 3315-3320 (2005)

Segura, J.A., Donadio, A.C., Lobo, C., Matés, J.M., Márquez, J., Alonso, F.J. Inhibition of glutaminase expression increases Sp1 phosphorylation and Sp1/Sp3 transcriptional activity in Ehrlich tumor cells. Cancer Lett. 218, 91-98 (2005)

Pérez-Gómez, C., Campos-Sandoval, J.A., Alonso, F.J., Segura, J.A., Manzanares, E., Ruiz-Sánchez, P., González, M.E., Márquez, J., Matés, J.M. Coexpression of glutaminase K and L isozymes in human tumour cells. Biochem. J. 385, 1-8 (2005)

Lora, J., Alonso, F.J., Segura, J.A., Lobo, C., Márquez, J., Matés, J.M. Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells. Eur. J. Biochem. 271, 4298-4306 (2004)

Castell, L., Vance C., Abbott R, Márquez, J., Eggleton, P. Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J. Biol. Chem. 279, 13305-13310 (2004)

Campos, J.A., Aledo, J.C., Segura, J.A., Alonso, F.J., Gómez-Fabre, P.M., Núñez de Castro, I., Márquez, J. Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues. Biochim. Biophys. Acta 1648, 17-23 (2003).

Pérez-Gómez, C., Matés, J.M., Gómez-Fabre, P.M., del Castillo-Olivares, A., Alonso, F.J., Márquez, J. Genomic organization and transcriptional analysis of the human L-glutaminase gene. Biochem. J. 370, 771-784 (2003).

Olalla, L., Gutiérrez, A., Campos, J.A., Khan, Z.U., Alonso, F.J., Segura, J.A., Márquez, J., Aledo, J.C. Nuclear localization of L-glutaminase in mammalian brain. J. Biol. Chem. 277, 38939-38944 (2002).

Aledo, J.C., Rosado, A., Olalla, L., Campos, J.A., Márquez, J. Overexpression, purification, and characterization of Glutaminase-Interacting Protein, a PDZ-domain protein from human brain. Protein Express. Purif. 23, 411-418 (2001).

Olalla, L., Aledo, J.C., Bannenberg, G., Márquez, J. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. FEBS Lett. 488, 116-122 (2001).

Segura, J.A., Ruiz Bellido, M.A., Arenas Acrís, M., Lobo, C., Márquez, J., Alonso, F.J. Ehrlich ascites tumor cells expressing antisense glutaminase mRNA loss their capacity to evade the mouse immune system. Int. J. Cancer 91:379-384 (2001).

Aledo, J.C., Gómez-Fabre, P.M., Olalla, L., Márquez, J. Identification of two human glutaminase loci and tissue-specific expression of the two related genes. Mamm. Genome 11:1107-1110 (2000).

Gómez-Fabre, P., Aledo, J.C., del Castillo-Olivares, A., Alonso, F.J., Campos, J.A., Núñez de Castro, I., Márquez, J. Molecular cloning, sequencing and expression studies of the human tumor glutaminase. Biochem. J. 345:365-375 (2000).

Lobo, C., Ruiz-Bellido, M.A., Aledo, J.C., Márquez, J., Núñez de Castro, I. y Alonso, F.J. Inhibition of glutaminase expression by antisense mRNA decreases growth and tumorigenicity of tumor cells. Biochem. J. 348:257-261(2000).

Segura, J.A., Barbero, L.G., Márquez, J. Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation. Immunol. Lett. 74:111-115 (2000).